From the 27 October 2018, the following substances require a licence and permit, issued by the Office of Drug Control, in accordance with Regulation 5 of the Customs (Prohibited Imports) Regulations 1956.

• Acryloylfentanyl (otherwise known as acrylfentanyl)
• N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide (otherwise known as AB-CHMINACA)
• 4-amino-3-phenylbutyric acid (otherwise known as phenibut)
• 4-fluoroamphetamine (otherwise known as 4-FA)
• 4-fluoroisobutyrfentanyl (otherwise known as 4-FIBF or pFIBF)
• Furanylfentanyl
• Methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate (otherwise known as 5F-MDMB-PINACA or 5F-ADB)
• Ocfentanil
• Tetrahydrofuranylfentanyl (otherwise known as THF-F)